The recommended timelines are: Semaglutide: stop at least 2 months before trying to get pregnant Tirzepatide: stop at least 1 month before If you find out youre pregnant while taking a GLP-1 medication, speak with your healthcare provider
At that point, your plan will determine whether it will cover the drug
Blood levels of AMH are correlated with number of ovarian follicles and have been found to be two to four times higher in women with PCOS than without
discussion 1146-1139
What to supplement: Methylated B vitamins at moderate doses SAMe supplements under supervision Trimethylglycine (TMG/betaine) to support methylation Supplements that may help regardless of cause: For oxidative stress and glutathione support: NAC (N-acetylcysteine): provides cysteine directly Glycine: another glutathione building block Glutamine: supports gut health and glutathione Vitamin C: antioxidant support Alpha-lipoic acid: regenerates glutathione Selenium: supports glutathione peroxidase The careful approach to supplementation: Step 1: Identify the root cause Test B12, folate, and other relevant markers Assess diet and protein intake Consider genetic testing (MTHFR, CBS, COMT) Evaluate for oxidative stress, inflammation, or toxic burden Step 2: Address foundations first Optimise diet (see foods section) Reduce toxic exposures Support gut health Manage stress Improve sleep Step 3: Start low and go slow Begin with lowest effective doses Introduce one supplement at a time Monitor symptoms carefully Adjust based on response Step 4: Retest and reassess Recheck homocysteine after 2-3 months Monitor symptoms and overall health Adjust supplementation accordingly Work with a knowledgeable practitioner: Low homocysteine is complex and requires individualised treatment
However, they may request additional details or recommend further assessment if needed
